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Recommendations for the peri-operative management of patients taking sodium-glucose cotransporter-2 inhibitors [1] : The risk of peri-operative ketoacidosis and mitigation strategies should be discussed with the patient using a shared decision-making approach." "Sodium-glucose cotransporter-2 inhibitors should be omitted the day before and the day of a procedure

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Therefore, modeling approaches can be valuable for examining the extent of pharmacokinetic DDIs driven by these mechanisms

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e Promoting binding to albumin