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Long-Term Semaglutide Use: Safety and Efficacy Data Studies tracking patients on semaglutide for 23 years show sustained weight loss and stable metabolic improvements when the medication is continued

The FDA-approved prescribing information for Mounjaro (tirzepatide for diabetes) does not list anger or irritability as recognized adverse effects

Retatrutide (LY3437943) is an investigational compound that has not been approved by the FDA as of June 2026

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Final Takeaway on Retatrutide vs Zepbound The Retatrutide vs Zepbound comparison comes down to a triple-agonist versus a dual-agonist approach to weight management