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The most common treatment-emergent adverse events were gastrointestinal, and the majority were of mild to moderate severity and resolved by the end of the study

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Body weight loss was more pronounced with tirzepatide than with semaglutide (LSM estimated treatment difference, 1.9, 3.6, and 5.5 kg, respectively

Retatrutide is a novel synthetic GIP, GLP-1 and glucagon receptor agonist which is expected to deliver substantial body weight reduction as well as improved glucose homeostasis and reduction in insulin resistance, lipids, and blood pressure

This is mechanistically different from older approaches to weight loss

Reward contributions to serotonergic functions