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Rare antagonistic leptin variants and severe, early-onset obesity

Although our dataset was not powered to formally test interaction terms, prior literature has suggested that combinations of risk factors may have multiplicative effects on pancreatitis risk

Real-world evidence supporting tandem control-IQ hybrid closed-loop success in the Medicare and Medicaid type 1 and type 2 diabetes populations

Naturally occurring variation in GLP1R cannot replicate that level of activation, which is why we don't see GLP1R variants with dramatic effects on BMI

Unlike traditional investigational peptides that activate only one biological pathway, Retatrutide was engineered to interact with three different receptors using one carefully designed molecule