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GLP-1R are expressed in both glomeruli and renal tubules, suggesting a direct effect on kidney function

& Sesti, G

14 Obesity can also impact the pharmacokinetics of therapies through changes to volume of distribution and drug clearance, 15 and may negatively alter the efficacy of therapies used to treat IBD

Using real-world data to evaluate the association of incretin-based therapies with risk of acute pancreatitis: a meta-analysis of 1,324,515 patients from observational studies

This change, effective as of February 21, 2025, impacts compounding pharmacies that had been producing off-brand versions during the shortage