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It facilitates the cell-surface activation of pro-MMP-2 by forming a tri-molecular complex with membrane type 1-MMP (MT1-MMP), which is critical in maladaptive cardiovascular ECM remodelling [130]

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1,41 SIRT1 also acts as a deacetylase and inhibits HIF-1, one of the factors needed to activate the Warburg effect

Hyatt JK