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doi: 10.1001/jama.2016.7602 21 Uptodate

It is unknown whether GLP-1 receptor agonists cause thyroid C-cell tumors, including medullary thyroid carcinoma (MTC), in humans, as the human relevance of GLP-1 receptor agonist-induced rodent thyroid C-cell tumors has not been determined

And protein, the very building block of hair, often falls to inadequate levels when appetite suppression from medications like semaglutide reduces total caloric intake by 30-40%

Depending on the exact brand name drug, GLP-1s are FDA-approved to help manage type 2 diabetes, to facilitate weight management, or to help with both

more frequent at higher concentrations Diarrhea common during early exposure or escalation periods Constipation reported alongside other GI disturbances Increased heart rate average increase of roughly 2 to 3 beats per minute Administration site reactions ranging from mild redness to localized nodules Gallbladder disorders including gallstones, especially at higher concentrations and longer durations Acute kidney injury primarily linked to volume contraction from GI fluid loss Pancreatitis a labeled risk, though large meta-analyses show no significant increase vs

As compared to loop diuretics, SGLT2-i may distinctly regulate the interstitial versus intravascular compartment selectively reducing interstitial oedema, which has been observed in HF and DKD, with minimal change in blood volume
