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According to SURMOUNT trial data, gastrointestinal side effects including heartburn were most pronounced during these dose transition periods and typically improved within 4 to 8 weeks at a stable dose

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SUSTAIN-2, SUSTAIN-3, and SUSTAIN-4 all enrolled patients already on metformin and showed mean A1C reductions of about 1.5 to 1.8% with semaglutide 1.0 mg on top

Recognizing and Managing Semaglutide Side Effects from Overconsumption Eating too much on semaglutide often triggers nausea, which typically peaks 1-2 hours after a large meal and subsides within 2-4 hours as your stomach empties

The STEP 4 trial demonstrated that participants who discontinued semaglutide regained two-thirds of their lost weight, emphasising that medication is most effective as part of a comprehensive lifestyle intervention

A history of pancreatitis (inflammation of the pancreas)