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Albiglutide, dulaglutide, exenatide, liraglutide, lixisenatide, orforglipron and semaglutide used in the clinic are monoGLP-1RAs, tirzepatide acts not only on GLP1R, but also on glucose-dependent receptors of insulinotropic peptide (GIP), and retatrutide is a triple agonist of GLP-1, GIP and glucagon receptors

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After propensity-score matching, the two cohorts (241 in each cohort, mean age 51.8 years, 39.0% women, 32.6% black, 44.4% white, 5.8% Hispanic) were balanced (see Supplementary Table S3 in the Supplementary Appendix)