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Today's oral GLP-1s give 13-15% weight loss at 36 weeks (orforglipron Phase 2)

Slower injection allows the tissue to accommodate the incoming fluid gradually, reducing pressure and discomfort

doi: 10.1093/ije/dyh185

The naltrexone component blocks opioid receptors that respond to food pleasure

The American College of Gastroenterology (ACG) guidelines for the diagnosis and management of DGp state that a combination of appropriate symptoms and signs, along with delayed gastric emptying in the absence of gastric outlet obstruction or ulceration, is required to establish the diagnosis of DGp [4]