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A small number of patients have reported new or worsening depression, mood changes, or suicidal thoughts during GLP-1 treatment

The relationship between weight and self-esteem operates through multiple pathways

Isken F et al (2008) Deficiency of glucose-dependent insulinotropic polypeptide receptor prevents ovariectomy-induced obesity in mice

After a real break, restarting means going back to a lower dose and stepping up again, the same way you started, so the side effects dont hit all at once

Varughese MS, Kalidindi S

It's a catastrophic error that physically breaks the molecules