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NICE NG28 GLP-1 RA or tirzepatide should be added as further therapy for T2D with obesity after at least 3 months of initial therapy if glycemic targets are not met

For patients using GLP-1 therapy, the goal should not be scale weight alone

Tirzepatide is one option that may be evaluated as part of a structured, physician-guided approach, depending on health history and program goals

This improved convenience has led to greater patient acceptance and better treatment compliance compared to other complex anti-diabetes regimens

Combination therapy should only be pursued under close medical supervision with careful monitoring of cardiovascular parameters and gastrointestinal tolerance

It works by depleting substance P, a neurotransmitter involved in pain signaling