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References (this section): Eli Lilly: notes GI side effects commonly reported and often during dose escalation (Phase 2 summary) NEJM (2023): safety/adverse events in Phase 2 publication Is retatrutide FDA approved

Additionally, data was collected from ELIXA, LEADER, EXSCEL, SUSTAIN-6, HARMONY, PIONEER 6, REWIND, and AMPLITUDE-O [53, 54, 56, 5963]
A notable study showcased that participants receiving GLP-1 agonists reported a mean weight loss ranging between 3.0 and 3.6 kg over six months
For patients with existing cardiovascular risk factors, this safety profile matters significantly

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