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It is one of the most extensively studied metabolic peptides in clinical research, with approved pharmaceutical formulations (Ozempic, Wegovy) demonstrating its significance in the incretin pathway

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In combination with neuropsychiatric drugs, GLP-1RAs did not increase the risk of developing SSIBs

Use In Specific Populations 8.1 Pregnancy Risk Summary Based on animal data showing adverse renal effects, XIGDUO XR is not recommended during the second and third trimesters of pregnancy