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Description
Observation periods included the in-trial period (that is, while in the trial, regardless of treatment discontinuation or rescue intervention) and the on-treatment period (with trial product)

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Kormilitzin, Z

Insulin resistance represents a condition neither sufficient nor necessary for the development of type 2 diabetes Insulin resistance is not sufficient for the development of T2D since the study of rare forms of primary insulin resistance has shown that T2D is not necessarily present in these cases [23]

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Therefore, it is possible that the inactive forms are not actually inactive and act on currently unidentified signalling pathways and this seems likely to be the case as it is very unlikely that evolution has developed such an ATP-wasteful response