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Customize this Structure of Semaglutide-bound Glucagon-Like Peptide-1 Receptor (GLP-1R) in Complex with Gs Protein template with BioRender

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Both ligands had similar cAMP potency but the exendin-4-C16 showed 2.5-fold bias towards G protein recruitment and a 60% reduction in -arrestin-2 recruitment efficacy compared to exendin-4, as well as reduced GLP-1R endocytosis and preferential targeting towards recycling pathways