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C., Benabbad, I., Zhang, X

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Acute kidney injury (AKI) is a risk highlighted in FDA labels for these medications, particularly during episodes of severe dehydration from gastrointestinal symptoms

The clinical trial evidence on duration The landmark STEP trials for semaglutide and SURMOUNT trials for tirzepatide provide the clearest data on what happens at different treatment durations

These can include differing bioavailabilities, halflives, tissue specificity and pharmacokinetics (Capozzi et al., 2018)