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The American Diabetes Association Standards of Care emphasize the importance of monitoring for adverse effects and adjusting treatment as needed to optimize tolerability while maintaining therapeutic benefit

It is well-known that most peptide molecules cannot cross the blood-brain barrier (BBB)

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They ran four parallel studies based on different patient profiles: ADM trial: Patients with type 2 diabetes (T2D), comparing newer GLP-1 RAs to older GLP-1 RAs, sulfonylureas, and other anti-diabetic medications (ADMs)