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Berberine has been studied for its potential role in supporting healthy intestinal function

Researchers designing long-term protocols might consider whether the additional 3 percentage points of weight loss at 12mg versus 8mg justifies the higher dropout risk for their specific application

In the STEP-1 trial (68 weeks), adults on semaglutide lost a mean of 14.9% of body weight versus 2.4% on placebo

Ahmad E, Lim S, Lamptey R, Webb DR, Davies MJ
A similar drop in waist circumference were noted in SURPASS-4, and this reduction was sustained through 104 weeks [51, 53]

It's a type of drug called a GLP-1 agonist
