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Moreover, the synergistic regulation of RA pathogenic cells and RA microenvironment is explored to exploit the interrelated and complementary relationship between RA pathogenic cells and microenvironment

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Keywords: GLP-1RA, Model-based meta-analysis, Obesity, Weight reduction Graphical abstract Highlights Offers a detailed comparison of the efficacy, potential influencing factors and safety profiles among various GLP-1RAs

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8.2 Safety evaluation and long-term risk management Chronic peptide therapy raises safety considerations that differ in some respects from those of small molecules ( Experience with GLP-1 receptor agonists underscores the importance of contextualizing safety signals rather than interpreting them in isolation