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doi: 10.1002/fft2.329

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GLP-1 medications are not recommended during pregnancy or breastfeeding, and some (like semaglutide) should be discontinued at least 2 months before a planned pregnancy

[DOI] [PubMed] [Google Scholar] 31.Adrian TE, et al

If you have obesity and are considering treatments that can lead to significant weight loss, you may be wondering how the two leading options compare: bariatric surgery, which permanently alters the digestive tract, versus powerful new appetite-suppressing medications like semaglutide (Ozempic, Wegovy) and tirzepatide (Mounjaro, Zepbound)

GLP-1 directly regulates insulin secretion, while GLP-1 RAs have the potential to improve insulin sensitivity and glucose homeostasis by attenuating inflammatory pathways such as NF-B and the NLRP3 inflammasome signaling, thereby mitigating IR [40]