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Many literatures proved that GLP-1 derivatives performed neuroprotective effects and inhibited neuronal apoptosis ( Figure 1 There are also a type of non-peptide small molecules, which are mainly extracted from herbal medicine, such as Cornus officinalis , Gardenia jasminoides , Rehmannia glutinosa , Lamiophlomis rotata , and Strychnos nuzi ( Even for patients without complications of diabetes, their cognitive functions were still significantly improved (28, 29)

25,26 Therefore, lifestyle change (such as a low-carbohydrate ketogenic diet) is still the main treatment method, 27 although some drugs for treating diabetes, such as metformin, -glucosidase inhibitor (AGI), dipeptidase-IV (DPP-IV) inhibitors, and glucagon-like peptide-1 receptor agonist (GLP-1 RA), may help people who are overweight or obese or who have a history of hypoglycemia

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As outlined in The American Journal of Managed Care (AJMC), unregulated or fraudulent products obtained online lack rigorous quality controls, increasing the risk of dosing errors, hypoglycemic shock, and adverse health outcomes

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