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These patients include: Hannah Nylander-Asplin , Minneapolis-based runner who lost 75 pounds over a year and a half and gained enough energy and mobility to go from running a mile to completing a marathon Deanna and Mitchell Taylor , Atlanta-based husband and wife who together lost 41 pounds on Ro and have increased energy and mobility to keep up with their young kids Greg Olson , Colorado-based cyclist who lost 78 pounds in 9 months and saw improvements in his confidence on Ro "Healthier on Ro" builds on Ro's mission to fight for patients and expand access to GLP-1 treatment through personalized, online care

INTRODUCTION Obesity is a major public health problem worldwide, affecting more than 2 billion adults

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Here we show that chronic stimulation of the GLP-1R increases glycolysis and ATP production in -cells through transcriptional activation and expression of glycolytic genes