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This is the only oral GLP-1 that is FDA approved for primary and secondary MACE reduction in adults with T2DM at high risk for these events, including patients with existing heart disease

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Entry of exendin-4 into brain is rapid but may be limited at high doses

Taking these medications individually or in combination may lead to potential side effects

In another study, the same treatment in 19 participants with obesity and diabetes was associated with an improved MoCA score, olfactory test total score and enhanced odor-induced right parahippocampus activation 46