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This, in turn, stimulates downstream signaling elements dependent on both protein kinase A (PKA) and exchange protein directly activated by cAMP (EPAC) activation, which triggers the opening of voltage-dependent calcium channels (VDCCs), resulting in insulin exocytosis [24, 25]
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Recent findings indicate that the anti-inflammatory effects of GLP-1RAs, mediated through GLP-1R in CNS neurons (268) and intrahepatic lymphocytes (269), play an important role in their antiatherogenic actions
Other medications that are frequently mistaken for GLP-1 agonists include: Phentermine is a sympathomimetic amine appetite suppressant, not a GLP-1
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[DOI] [PMC free article] [PubMed] [Google Scholar] 261.Punjabi M., Arnold M., Ruttimann E., Graber M., Geary N., Pacheco-Lopez G
