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A 52 weeks, controlled trial, investigated the efficacy of GLP-1RAs of liraglutide (1.2 and 1.8 mg/day) vs

for example, if the steroid dose is reduced or increased by 50%, the insulin dose will be reduced or increased 25%, respectively[19,26]

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At a population level, 70% of people prefer oral medications over injections

Therefore, multi-targeting or unimolecular peptides possessing combinatorial agonism at GIPR, GLP-1R and GCGR have been extensively explored and more than a dozen peptides including two GIPR/GLP-1R dual agonists, ten GLP-1R/GCGR dual agonists and five GIPR/GLP-1R/GCGR triagonists have entered into clinical development (Supplementary Fig