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Tirzepatide and retatrutide are also glucose-dependent insulinotropic polypeptide (GIP) agonists

Diabetes Care (2015) 38(2):26470

Additionally, they have a beneficial effect on blood sugar levels, which can be especially helpful for people with type 2 diabetes

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Two randomized control clinical trials reported conflicting effects on bone mineral content (BMC) and bone mineral density (BMD): one trial demonstrated preservation of BMC with GLP-1 use, while the other found no significant difference in BMC or BMD between treatment and control groups