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Action on peripheral glucose homeostasis and fuel partitioning Data from healthy rodents Data from our laboratory, and from others, have shown that brain GLP-1 receptor signaling has metabolic effects on peripheral glucose tolerance

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Downregulating the expression of miR-23a and increasing the expression of the mitochondrial protective gene peroxisome proliferators-activated receptor- coactivator-1 (PGC-1) can exert an anti-apoptotic effect on human hepatocytes [34]

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