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Description
Starting a GLP-1 drug (short for glucagon-like peptide-1 receptor agonists), such as semaglutide or tirzepatide, often comes with ups and downs

Clinical studies have documented reductions in total and free testosterone levels, increases in SHBG, and improvements in menstrual regularity following treatment with liraglutide or semaglutide

In rats, GLP-1 (7-36amide) and, perhaps paradoxically, the GLP-1R antagonist exendin (939), dose-dependently cause relaxation of the aorta, potentially via elevation of cAMP formation and activation of K ATP channels [624]

47,48 Human studies yield somewhat mixed results regarding the impact of GIP on bone metabolism

[DOI] [PubMed] [Google Scholar] 26.Seo S

Srivastava, R
