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Description
Although rarely acknowledged, case reports and emerging evidence suggest GLP-1 receptor agonists may contribute to bowel obstruction

2003;284:R1427R1435

This GLP-1 hormone binds to the G protein-coupled GLP-1 receptor (GLP-1R) and activates key intracellular metabolic pathways
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In those already addicted, the GLP-1 drugs were linked to lower risks of hospitalization, overdose and death, according to the study

That R&D cost must be recouped through pricing, which is standard pharmaceutical economics
