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5 Persistence and discontinuation Persistence with GLP-1 therapy has been a major concern

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pain, lumps, bruising, rash) Your injection routine, such as how you prepare your dose and where you inject it This information helps your provider determine the best next steps to minimize your discomfort

Central administration of GLP-1 in rats and mice stimulates the HPA axis and increases secretion of corticosterone, and this is accompanied by increased cFOS immunoreactivity in CRH-positive neurons in the PVN [668,698,814]