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GLP-1 receptor agonists like semaglutide and tirzepatide are commercially available in fixed pre-filled pens and certain multidose formats

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Moreover, exogenous administration of GLP-1R agonists failed to reduce food intake (and gastric emptying) in Glp1r Wnt1- / - mice or Glp1r conditional KO mice, reflecting the importance of neural GLP-1R populations for the pharmacological control of GLP-1-regulated feeding [194,198]