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The jump from 8mg to 12mg carries a disproportionate increase in GI symptoms relative to the modest additional weight loss

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doi: 10.1126/science.1173635 209 GuoZMitchell-RaymundoFYangHIkenoYNelsonJDiazVet al

Using a 29 to 31 gauge needle, allowing the solution to reach room temperature, and injecting slowly all minimize discomfort

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