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In an attempt to develop a strategy to prolong the physiological t1/2 and enhance the potency of GLP-1, a fusion protein consisting of active human GLP-1 and mouse IgG1 heavy chain constant regions (GLP-1/Fc) was generated

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Here, the authors review the physiological roles of GLP-1, the potential renoprotective mechanisms of incretin-based therapies and the available renal outcome data from clinical trials.