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Overall, the results of this study indicate that LY3437943 has a safety and tolerability profile similar to other incretins, with pharmacokinetic and pharmacodynamic outcomes that support further clinical evaluation
Recent advances in biomaterial science have also enabled the incorporation of Ex-4 into novel scaffold systems using electrospinning methods
The GLP-1 and GIP arms slow gastric emptying and blunt appetite (that is where nausea comes from), while the glucagon arm nudges energy expenditure and hepatic fat handling
doi: 10.1038/d41573-022-00094-2
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Major clinical trials, including the STEP-1 extension and SURMOUNT-4, provide valuable insights into this process
