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Interestingly, exogenously administered GIP and GLP-1 seem to access the brain predominately via leaks in the bloodbrain barrier, where the underlying neuronal tissue has dense expression of their receptors [11,12,13, 17] (Fig

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The GLP-1 receptor agonists currently approved in the United States for the treatment of type 2 diabetes include exenatide (administered twice daily), liraglutide and lixisenatide (administered once daily), and the once-weekly agents exenatide extended-release, albiglutide, and dulaglutide

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