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GLP-1 Activation Slowed gastric emptying and central appetite suppression, the same mechanism behind semaglutide's clinical effect

Side effects peak during the first 1-2 weeks after dose escalation and generally diminish within 3-5 weeks as the body adjusts

This weekly dosing schedule is consistent with other agents in the incretin-based injectable class, such as semaglutide (Ozempic/Wegovy) and tirzepatide (Mounjaro), and is designed to maintain stable plasma drug concentrations throughout the week whilst minimising the burden of frequent injections

Brown D, Clarke JHR

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