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Chronic inflammation, on the other hand, is associated with conditions like type 2 diabetes, metabolic syndrome, obesity, cancer, arthritis, and bowel diseases like Crohns disease and ulcerative colitis (2)

Camilleri recently reviewed multiple studies that assessed lung aspiration in endoscopic procedures and found the risk to be low, with studies showing rates that were similar to patients not taking GLP-1 drugs: 4.8 versus 4.6 cases per 10,000 patients, respectively (4)

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Phase II trials for tirzepatide and survodutide, a GLP-1/glucagon receptor co-agonist, have also shown positive outcomes in people living with MASH and obesity, demonstrating reduction of inflammation without worsening of fibrosis (4, 69)

December 31, 2024

In chronic PD mice, the triple receptor agonist HM15211 protected against dopaminergic neuronal death, decreased -synuclein accumulation, and prevented nigrostriatal neurodegeneration by mitigating the inflammatory response and lipid peroxidation [124, 125]
