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If you are water fasting using the full-day fast or alternate-day fast strategies, you are just as safe as with any other form of intermittent fast, and only have an elevated risk if you have gout, type 1 or type 2 diabetes, eating disorders, or are elderly, sick, or pregnant/breastfeeding

It is not as potent as long-acting opioids such as OxyContin or fentanyl, which are used for chronic or cancer-related pain

You still need to perform training and mobility work to stay limber and ambulatory

Dual PAK4-NAMPT inhibition impacts growth and survival, and increases sensitivity to DNA-damaging agents in waldenstrom macroglobulinemia

Diabetes 63(11):37113720

This theory is supported by the clinical data showing that tirzepatide produces comparable appetite suppression with less severe gastric emptying delay