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29 In a study involving 1,306 overweight or obese individuals receiving 2.4 mg of semaglutide, approximately 6% and 12% weight loss was observed at 12 and 28 weeks, respectively, and total fat mass decreased by approximately 20% after 56 weeks of treatment

GLP-1/GLP-1R signaling in regulation of adipocyte differentiation and lipogenesis

doi:10.3390/ph18050668 19

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One meta-analysis concluded that GLP-1 receptor agonists produce weight loss mainly through fat mass reduction, with comparatively modest reductions in lean body mass