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A study published in the Journal of Biological Chemistry in 2015 established the mechanistic link between butyrate-producing bacteria and GLP-1 production at the cellular level

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(2014) showed in a mouse model that hydroxytyrosol prevented diet-induced obesity, hyperglycaemia, and insulin resistance over a 17-week supplementation period, with effects on fasting glucose comparable to metformin

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This treatment algorithm naturally selects people with longer disease duration and elevated cardiometabolic risk