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A systematic rotation patternsuch as dividing each thigh into upper, middle, and lower zones and cycling through them weeklyensures tissue recovery between injections and reduces local inflammatory response that can impair absorption rates

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In mice (half-life 24 h), plateau is reached in 5-6 days

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In light of all these studies, it should be emphasized that blood glucose should be monitored regularly when initiating or adjusting antidepressant therapy, and patients with diabetes should also be monitored for depressive symptoms due to the bidirectional relationship