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In the STEP UP trial, average weight loss was about 21 percent at 72 weeks for those who stayed on treatment and 19 percent when including all participants

Biospecimen Core Core Director: Andrew Bellizzi, MD Michael ORorke, PhD The Biospecimen Core provides a coordinated, centralized, and dedicated service for procuring, processing, and annotating high-quality biospecimens from patients in our Iowa NET Registry and SEER Residual and Iowa Virtual Tissue Repositories

Across the state, from Atlanta to Valdosta, these everyday challenges are becoming more common and more serious

They ran four parallel studies based on different patient profiles: ADM trial: Patients with type 2 diabetes (T2D), comparing newer GLP-1 RAs to older GLP-1 RAs, sulfonylureas, and other anti-diabetic medications (ADMs)

Regulatory milestones (2017 to 2024) Clinical development advanced along two parallel formulation tracks: a subcutaneous formulation studied in the SUSTAIN and STEP programs, and an oral tablet formulation using an absorption-enhancer excipient studied in the PIONEER program

His key contributions include: Discovery and initial characterization of MOTS-c as the first mitochondrial-encoded nuclear transcription regulator Demonstration of MOTS-c as an exercise-induced factor that improves age-dependent physical decline Elucidation of bi-genomic communication mechanisms between mitochondrial and nuclear genomes Investigation of MOTS-c polymorphisms associated with longevity in specific populations Studies on MOTS-c effects across aging, metabolic disease, and neurological applications His laboratory continues to investigate molecular mechanisms underlying MOTS-c function, therapeutic potential in age-related diseases, and translational applications for human health and longevity
