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Clinical trial data for tirzepatide did not identify increased rates of thyroid dysfunction or autoimmune thyroid disease exacerbation, though patients with significant thyroid disease were typically excluded from pivotal trials

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Increasing prescriptions of GLP-1 RAs in adolescents These data indicate a substantial rise in AOM semaglutide, following its approval for adolescent obesity management in late 2022 ( 6 )

Tirzepatide may be considered when semaglutide is not tolerated, although renal benefits remain to be confirmed in dedicated trials (TREASURE-CKD, ClinicalTrials.gov ID NCT05536804)

But it does not work

Both have the same main ingredient, but they are used for different reasons