glp 1 gip gcg receptor agonist LY3437943, a novel triple glucagon, GIP, and GLP-1 for glycemic control and weight loss: From discovery to clinical proof of concept Glucagon Receptor Agonist - an
Description
Robert Kushner, who helped bring them to market, breaks down how they actually work, who benefits most, and why they're a long-term commitment rather than a quick fix

Lifestyle change is a critical step two

There is a reduced price if you pay in cash (Zebbound KwikPen) Members receive unlimited provider messaging and 1:1 health coaching support

In a 26-week RCT (PIONEER 5), involving 163 patients randomized to oral semaglutide (14 mg once daily) and 161 patients to the placebo, oral semaglutide was shown to provide a superior glycemic control (estimated treatment difference of 0.8%) and body weight loss (estimated treatment difference of 2.5 kg) than placebo and was found not to affect renal function

Finkle and Brost, 2025

These drugs, like Wegovy (Semaglutide) and Zepbound (Tirzepatide), have been game changers
