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Obesity alone increases the risk of headache and migraine by 27%, suggesting that weight loss itself is an important goal in the symptomatic treatment of IIH (20)

however, while it effectively lowers glycated hemoglobin (HbA1c), it has minimal effects on weight loss and limited durability in glycemic control

These dual actions likely explain its broader benefits compared to single-pathway GLP-1 agonists like dulaglutide

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Currently, the use of GLP-1 RAs in individuals with a personal or family history of medullary thyroid carcinoma (MTC) or multiple endocrine neoplasia syndrome type 2 (MEN2) is contraindicated
