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Stage 1 includes individuals with higher risk of developing dysglycaemia (defined based on validated country-specific risk scores than those with stage 0 or normal -cell function, whose high insulin resistance would be compensated by increased insulin production and glucose remains near normal despite gradual minimal decline in -cell function or mass
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In this model, we administered semaglutide (0.05 mg/Kg intraperitoneally) on a weekly basis to evaluate its potential as a therapeutic option for depression and anxiety
