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Holst JJ, Andersen DB, Grunddal KV

Application Insights Why Did the Type 2 Diabetes Mellitus Segment Dominate the GLP-1 Analogues Market in 2025
Alogliptin after acute coronary syndrome in patients with type 2 diabetes: a renal function stratified analysis of the EXAMINE trial

S6 show that both GLP-1RA and SGLT-2 inhibitors were associated with a lower risk (13% and 14%, respectively) as compared with placebo and DPP-4 inhibitors (11% and 12%, respectively), although the difference in risks was significant for SGLT-2 vs DPP-4 inhibitors only

The journey began in the 1960s with the formulation of the incretin hypothesis, which proposed that intestinal hormones stimulate insulin secretion

NNC00902746 (RG7697), a fatty acidmodified dual GIPR and GLP-1R agonist, was evaluated in clinical trials involving participants with T2D, indicating notable enhancements in glucose tolerance and weight reduction when compared to those who received a placebo [131]
