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After the first hospitalization for ASCVD ( n =518,572), 13.7% ( n =71,259) of patients initiated SGLT2i with a median of 10.6 months

Metabolism 164:156113 Linge J, Birkenfeld AL, Neeland IJ (2024) Muscle mass and Glucagon-Like Peptide-1 receptor agonists: adaptive or maladaptive response to weight loss

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As patients and providers move to try lower-cost doses with fewer side effects, some demand may shift from full-strength prescriptions

The cormorbidities often associated with HFpEF such as obesity, diabetes mellitus, and hypertension as well as the metabolic changes associated with them are known to induce a state of inflammation that affects cardiac metabolism, as well as coronary vascular injury and ischemia [5]