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Efforts to synthesize GLP-1RAs for clinical applications date back to the 1990s (1)

38 The Pharmaceutical Benefits Advisory Committee has recently recommended semaglutide 2.4 mg be listed on the PBS for adults with established cardiovascular disease and BMI 35 kg/m 2 or higher, or 32.5 kg/m 2 or higher for Asian, Aboriginal or Torres Strait Islander populations

Its this: losing weight on a GLP-1 means losing a meaningful proportion of lean tissue alongside fat, unless you take specific steps to preserve it

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